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KMID : 0361020240670040234
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Korean Journal of Otolaryngology - Head and Neck Surgery
2024 Volume.67 No. 4 p.234 ~ p.239
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Dupilumab in the Treatment of Eosinophilic Otitis Media: A Case Report
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Kim Jong-Kwan
Jin Myung-Ho
Kim Min-Woo
Kwak Min-Young
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Abstract
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Eosinophilic otitis media (EOM) differs from classic chronic otitis media as it is a refractorydisease with the accumulation of eosinophils in thick mucinous middle ear effusion and mu-cosa. A 66-year-old male with a history of asthma, chronic sinusitis with polyposis, nasal pol-yposis, and multiple sets of ventilation tubes was presented to our center for the managementof hearing loss and otorrhea. He had a history of consistent otorrhea and hearing loss evenwith the ventilation tube insertions and medical treatment. Both systemic and intratympanicsteroid was administered, but the effect was insignificant and other systemic adverse effectsoccurred. Finally, the otologic symptoms including hearing loss and otorrhea improved afterbeing given a Dupilumab injection. This case report discusses Dupilumab treatment resultingin remission in a patient suffering from refractory EOM.
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KEYWORD
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Dupilumab, Eosinophil, Hearing loss, Otitis media, Steroids
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